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Why Adding A Pragmatic Free Trial To Your Life's Journey Will Make The…

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Pragmatic Play Free Trial

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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are typically described as a focus on the practical aspects of designing a study, including the recruitment and consent process, as well as adherence and the use of routinely available equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which used various investigators and participants from different geographical regions. This type of heterogeneity which is essential for a pragmatic trial to be valid and lessen the chance of bias, is also necessary. However, too much heterogeneity can result in problems with the trial design.

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The aim of pragmatic trials is to replicate real-life scenarios and gain maximum credibility externally. They are usually commissioned by policy makers and practitioners to guide their decision-making. They can also be a great method to determine the cause-effect relationship between the intervention and its effects. However, they should not be used to substitute for the use of explanation studies.

The concept of pragmatism is controversial and there are questions about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 proposed an distinction between explanation-based studies, which support a physiological hypothesis or clinical hypothesis, and pragmatic trials that aid in policy and practice decision-making. They also proposed an approach to pragmatic trials, called PRECIS.2 This tool sought to define the features of a pragmatic study which includes recruitment, design and delivery of the intervention, as well as monitoring.

There is an encouraging trend in the number of pragmatic trials that have been published. A recent Medline search using the keywords naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs) resulted in 34 articles, shown in red in Figure 2. This indicates that the health science community is becoming increasingly sensitized to the subject of pragmatics. It is important to remember that the majority of these studies were conducted in primary-care settings.